The aim of the course is to develop the capability to students to study and design complete complicated mechanical systems, so that they will be safe, efficient, reliable, economical, and optimal. Through the appropriate learning, the students will develop skills that will enable them to invent suitable solutions to mechanical design problems. At a theoretical level, topics on creativity, decision-making, safety, reliability and optimization (classical, evolutionary, heuristic, …) with emphasis in applications for the design of systems of mechanisms used in automated production and handling of materials and goods, as well as for the betterment of human life in a safe and sustainable environment. A systematic application on suitable complete design projects will help in the understanding and the development of professionalism in the design of mechanical systems composed of machine elements, mechanisms, power supplies (mechanical, electrical, hydraulic, pneumatic etc), as well as in methods of proper control in static and dynamic conditions.